Female patient with a previous history of carcinoma and mildly decreased systolic function due to cardiotoxicity. She had a previous heart trauma and a dual chamber pacemaker implanted for sick sinus syndrome. Back for control, where a Cardio-HART (CHART) test is performed before Transthoracic Echocardiogram.


CHART report interpretation


Risk Assessment

The patient is 74 years old, hypertensive, dyslipidemic, a former smoker, and under high levels of stress. Medications: Candesartan (16mg), Indapamide (1.5mg), Triflusal (300mg), Atorvastatin (20mg)


HART-findings and HF prediction

HART-findings shows mild diastolic dysfunction, type impaired relaxation.

The estimated LVEF shows normal, preserved systolic function (LVEF=64%).

The probability of HFpEF is unlikely according to the CHART assessment.


HART Findings   HART Findings


AI automated ECG interpretation detected pacemaker spikes; otherwise ECG signal is in the normal range.

ECG Findings   ECG Findings



PCG result shows an increased fourth sound (S4) amplitude, inaudible frequencies, rather late S4, occur after P-wave, right before the first sound. The reason for this type S4 is in question.




The increased amplitude of the second sound can be a sign, but alone it is not considered pathological.



The MCG-based systolic time intervals show prolonged LV ejection time (LVET) or LV systolic time (LVST). However, the detection of Q onset seems to be shifted to earlier due to the pacemaker spikes, which may make uncertain the systolic time interval measurements.

MCG signal confirms the fourth sound activity, which means increased atrial systole. This is probably connected to diastolic dysfunction.




Echocardiographic Results

TTE confirms:

  • preserved systolic function (LVEF=59% with Simpson Mod BP) which means slight improvement in LVEF;
  • diastolic dysfunction type impaired relaxation – grade I (E/A=0.81, DT=213ms, E/e’(mean?)=9);
  • pacemaker in the right chambers



A previous CHART report was not available for comparison purposes, but the current CHART report correctly indicates the echocardiographic results based on bio-signals available in primary care.


What is CHART?

Cardio-HART or CHART is an AI cardiac diagnostic system for the non-invasive detection of early onset of 93% of all common heart diseases, including heart failure and heart valve disease. It is a direct replacement for ECG, augmenting it with Echo functionality, that is indicated for use in clinical care settings, including primary care.

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